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Simparica Flea & Tick Chewables for Dogs 2.8-5.5 lbs (Yellow)

4.6/5 (267 Reviews)
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  • Information
  • Directions
  • Safety
  • Benefits
  • Simparica Flea & Tick Chewables FAQ
Information
Simparica Flea & Tick Chewables
  • Pet
    Dog
  • Treatment For
    Flea & Tick
  • Health Benefits
    External Parasite Protection
  • Product Type
    Flavored Tablet
  • Parasites Covered
    Fleas, Ticks
  • Minimum Age
    6 Months
  • Minimum Weight
    2.8 Pounds
  • Protects For
    1 Month
  • Can Be Given Without Food
    Yes
  • Safe For Pregnant Dogs
    No
  • Recommended For
    Puppies 8 weeks of age and older
  • Key Ingredients
    Sarolaner

Simparica Flea & Tick Chewables for Dogs 2.8–5.5 lbs (Yellow)

Simparica Chewables for dogs Yellow is a monthly treatment that protects your furry friend from the most common external parasites. Just one chew is enough to safeguard dogs against flea and tick infestations for four weeks. This flea and tick chew for dogs works quickly. It begins killing fleas three hours after administration, according to a lab study referenced in the product label.

Simparica for 2.8–5.5 lbs dogs comes as a tasty chewable that dogs find appealing, making it easy for you to administer. This oral formula is effective against as many as six different tick species, providing broad tick coverage throughout the month. As a direct result of killing vector ticks (black-legged ticks), it is indicated to prevent Lyme disease (Borrelia burgdorferi) infections.

Suitable For

Simparica for dogs Yellow is suitable for use in puppies and dogs from 6 months of age, weighing between 2.8 and 5.5 lbs.

Active Ingredient

Sarolaner 5 mg

Ingredients: Sarolaner

Directions
How to Use Simparica Flea & Tick Chewables for Dogs

  • Treatment with Simparica chewables may begin at any time of the year.
  • Simparica Chewables should be administered orally as a single dose, once every month.
  • The chew can be given by hand, in the food, or like other oral tablets. When giving it with food, watch your dog for some time to ensure the complete dose is consumed. If you suspect that a part of the dose is missed, give another dose.
  • If you miss a dose, give one dose immediately and continue with the monthly dosing schedule.
  • For your dog's year-round protection, give Simparica the entire year without interruption.

The table below displays the available Simparica Chewable dosage packs based on your dog’s weight.

Simparica Chewable Dosing Table:

Dog Weight (lbs) Pack Color Sarolaner Per Chew (mg) Chews Administered
2.8 – 5.5 Yellow 5 One
5.6 – 11.0 Purple 10 One
11.1 – 22.0 Caramel 20 One
22.1 – 44.0 Blue 40 One
44.1 – 88.0 Green 80 One
88.1 – 132.0 Brown 120 One
For dogs over 132.0 lbs, administer the appropriate combination of Simparica Chews.
Safety

For Dogs:

Do not administer to dogs under 6 months of age or less than 2.8 lbs of body weight. You should use it with caution in dogs with a history of seizures or neurologic disorders. The safety of these chews has not been evaluated in breeding, pregnant, or lactating dogs.

For Humans:

Simparica Chewable is not for use in humans or any other animal species. Keep them away from children, pets and uninformed people. In case of accidental ingestion, consult a physician immediately.

Are there Any Specific Storage Instructions for Simparica Chews?

You should store Simparica Chewables at or below 30°C (86°F) with excursions permitted up to 40°C (104°F).

Benefits

What are the Key Benefits of Simparica Chewables for Dogs?

  • Month-long protection: A single chew provides continuous protection for 30 days.
  • Hassle-free administration: Comes in a palatable chew that dogs accept without fuss.
  • Wide tick-coverage: Safeguards against 6 different species of ticks.
  • Lyme disease prevention: Indicated to prevent Lyme disease infections by killing black-legged vector ticks.
  • Rapid action: Begins killing fleas within 3 hours and ticks in 8 hours.
Simparica Flea & Tick Chewables FAQ

How soon can I start treating my dog with Simparica?

Simparica Chewables are safe for dogs from 6 months of age, weighing at least 2.8 lbs. You may begin treating your dog with Simparica at any time of the year.

How is Simparica Chewable different from other flea and tick products?

Simparica Chewable for dogs is a flea and tick treatment that kills fleas and six different types of ticks, including American dog ticks, Lone star ticks, Gulf Coast ticks, Black-legged ticks, Brown dog ticks and Asian longhorned ticks.

How does Simparica Chew work?

Simparica Chewable contains sarolaner as its active ingredient. After ingestion, the formula is absorbed into the dog's bloodstream and skin tissues. Once fleas and ticks bite the treated dog, they ingest sarolaner, which disrupts the nervous system of these parasites and kills them.

How effective is Simparica Chewable?

According to a laboratory study referenced in the product label, Simparica begins killing fleas 3 hours after initial administration. It reduces the number of active fleas by more than 95% within 8 hours after flea infestation and provides complete flea efficacy 24 hours after treatment. The lab studies also indicated that it provides more than 95% effectiveness against ticks 48 hours post-infestation.

How frequently should I give my dog Simparica?

Simparica Chewable for dogs is a monthly flea and tick treatment and should be given once every month.

How quickly does Simparica kill parasites?

Simparica Chewable for dogs is a quick-action formula. According to the studies referenced by the manufacturer, it starts killing fleas within 3 hours and ticks in 8 hours.

Which ticks does Simparica Chewable kill?

Simparica Chewable kills six different types of ticks, including American dog ticks, Gulf Coast ticks, Lone Star ticks, Black-legged ticks, Brown dog ticks and Asian longhorned ticks.

How is Simparica Chewable different from Simparica Trio?

Simparica only contains sarolaner as its active ingredient. As a result, it is effective against fleas and six types of ticks (including the ticks that may transmit Lyme disease infections). Simparica Trio contains moxidectin and pyrantel in addition to sarolaner. It protects dogs against heartworm disease, intestinal worms, fleas, and six tick species (including the ticks that may transmit Lyme disease infections).

How does Simparica Chewable protect from Lyme disease?

Simparica Chewable for dogs kills black-legged ticks (deer ticks) and thus blocks the infections that may cause Lyme disease in dogs.

What happens if I miss a dose of Simparica?

If you miss giving a dose, give one Simparica chewable right away and continue with a monthly dosing schedule.

Simparica Flea & Tick Chewables Reviews

4.6
Average Rating 4.6 Based on 267 Reviews
  • 5 star
     157
  • 4 star
     108
  • 3 star
     1
  • 2 star
     0
  • 1 star
     1
58%
Recommend
58% of Reviewers Recommend This Product
Write A Review
4.6/5
Average Rating 4.6
Based on 267 Reviews
Monthly treatment Dec 10, 2025
An easy to use flea and tick treatment.
Was this review helpful? 0 2
Quick relief Dec 03, 2025
It kills fleas quickly and gives instant relief to my pet.
Was this review helpful? 0 2
Pretty much effective Nov 26, 2025
The treatment worked incredibly well to get rid of my pet's fleas.
Was this review helpful? 1 1
Trustworthy Nov 19, 2025
I completely trust thuis treatment for the well-being of my pet.
Was this review helpful? 0 1
Easy to chew Nov 13, 2025
It is very easy to chew for my pet.
Was this review helpful? 1 1
Quick results and no itching Nov 04, 2025
I noticed the scratching stopped within a day! The chews are small and super convenient. Love this brand.
Was this review helpful? 1 1
Fast relief, no scratching Sep 19, 2025
My poor pup was scratching nonstop until I tried Simparica. Within hours, fleas were gone. I love that it works so fast and keeps protecting her month after month.
Was this review helpful? 1 0
Finally, a Chew My Dog Loves Sep 12, 2025
My dog actually looks forward to his Simparica dose—it works fast and he hasn’t had a single flea or tick since.
Was this review helpful? 1 0
Simparica flea and tick medication Sep 09, 2025
Great price for this product! No problem getting my French bulldogs to eat this medication. They think it’s a treat!
Was this review helpful? 1 0
Fast and easy Sep 05, 2025
Fleas disappear quickly, and my dog happily eats the chew every month.
Was this review helpful? 1 0
Fast & effective Aug 26, 2025
Kills fleas before they can lay eggs. Noticeable difference in just hours.
Was this review helpful? 0 1
Quick and Easy Aug 19, 2025
Just one chew a month and no more scratching—huge relief for both of us!
Was this review helpful? 0 1
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