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Frontline Plus Large Dogs 45-88 lbs (Purple)

4.7/5 (256 Reviews)
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  • Information
  • Directions
  • Safety
  • Benefits
  • Frontline Plus FAQ
Information
Frontline Plus
  • Pet
    Dog
  • Treatment For
    Flea & Tick
  • Health Benefits
    External Parasite Protection
  • Product Type
    Topical
  • Parasites Covered
    Adult fleas, Ticks, Flea eggs, Larvae, Pupae, Chewing lice
  • Minimum Age
    8 Weeks
  • Minimum Weight
    5 Pounds
  • Protects For
    One month
  • Safe For Pregnant Dogs
    Yes
  • Recommended For
    8 weeks and older puppies
  • Key Ingredients
    Fipronil, s-Methoprene

Frontline Plus Large Dogs 45-88 lbs (Purple)

Frontline Plus for Large Dogs is a safe and effective treatment that protects your furry friend from common external parasites. Trusted by dog parents for over 20 years, this topical formula safeguards your dogs against fleas and ticks for 30 days. This fast-acting spot-on treatment for fleas starts working within hours and helps relieve your dog quickly.

Frontline Plus Purple flea & tick treatment provides comprehensive protection by eliminating all life stages of fleas (eggs, larvae, and pupae) and ticks (larvae, nymphs, and adults). Thus, it helps break the breeding cycle of these parasites, ensuring your dog remains safe from new infestations. This monthly spot-on treatment is suitable for dogs from 8 weeks, allowing you to protect your canine friend from an early age.

Suitable For

Frontline Plus Purple is suitable for dogs from 8 weeks of age, weighing between 45 and 88 lbs.

Active Ingredients

Fipronil 9.8%, S-methoprene 8.8%

Ingredients: Fipronil, S-methoprene

Directions
How to Use Frontline Plus for Dogs

  • Weigh your dog and get the dosage pack closest to the dog's weight.
  • Remove a pipette (applicator) from the package.
  • Open the pipette.
  • Hold it upright with the foil side toward you and snap the tip.
  • Part your dog's hair between its shoulder blades. Place the tip of the pipette just above the skin and squeeze.
  • Apply the entire contents of the pipette in a single spot.
  • Ensure you apply the liquid directly onto the skin, not on top of the hair coat.
  • Avoid contact with the treated dog until dry.

The table below shows the available dosage packs of Frontline Plus for Dogs based on your dog's weight.

Frontline Plus for Dogs Dosing Table

Dog Size Dog Weight Pack Color Active Ingredients (g/L) Tube Volume Tubes Administered
Small Dogs Up to 22.0 lbs Orange 9.8% Fipronil
8.8% (S)-methoprene
0.67 ml One
Medium Dogs 23.0 – 44.0 lbs Blue 9.8% Fipronil
8.8% (S)-methoprene
1.34 ml One
Large Dogs 45 – 88.0 lbs Purple 9.8% Fipronil
8.8% (S)-methoprene
2.68 ml One
Extra Large Dogs Over 88 lbs Red 9.8% Fipronil
8.8% (S)-methoprene
4.02 ml One
Safety

For Dogs:

Frontline Plus is for external use only. Do not administer it orally. It is not indicated for puppies younger than 8 weeks of age and less than 5 lbs of body weight. Frontline Plus can be used in pregnant, breeding and lactating dogs. When applying, avoid contact with the dog's eyes or mouth. Consult a vet before using it together with steroids, antibiotics, anesthetics, antihistamines, NSAIDs, or other topical treatments.

For Humans:

Frontline Plus is not indicated for use on humans. Keep it away from children and pets. Do not allow children or anyone to come in contact with the application site until the application is dry. Wash hands after handling the treatment.

General:

Do not use or store the product near heat or open flame. Do not contaminate water, food or feed during storage and disposal.

Are there Any Specific Storage Instructions for Frontline Plus?

Store it in the original container.

Benefits

Key Benefits of Frontline Plus for Dogs

  • Trusted & reliable: Providing effective protection for over 20 years.
  • Fast-acting: Eliminates fleas and ticks within hours of application, providing rapid relief.
  • Comprehensive protection: Kills all life stages of fleas and ticks, preventing future infestations. Protects from chewing lice & sarcoptic mange.
  • Long-lasting: Provides 30 days of uninterrupted protection.
  • Easy-to-apply: Comes as a topical solution, allowing ease of use.
  • Waterproof: Stays effective even after bathing or swimming.
Frontline Plus FAQ

How does Frontline Plus for dogs work?

Frontline Plus for dogs contains fipronil and S-methoprene as its active ingredients. After application, the active formula spreads over the dog's skin. It is localized in the hair and in the sebaceous glands, which act as a reservoir. These glands continuously replenish the formula onto the skin and hair coat.

Fipronil kills adult fleas and ticks, whereas S-methoprene targets life stages, preventing the laying of eggs and inhibiting larval and pupal development.

How often should I apply Frontline Plus to my dog?

Frontline Plus waterproof flea treatment for dogs should be applied once every month, year-round, for continuous protection against fleas and ticks.

Can I use Frontline Plus on puppies?

This monthly flea and tick treatment for dogs is indicated for use on puppies and dogs from 8 weeks of age, weighing 5 lbs or greater.

Is Frontline Plus waterproof?

Frontline Plus is a waterproof formula. It remains effective even after bathing or water immersion. For optimum results, your dog should remain dry for 24 hours after applying Frontline Plus.

Can I use Frontline Plus for dogs on other animals?

Frontline Plus for dogs is specifically formulated and approved for use on dogs only. You should not use it on other animals.

Does my dog need flea and tick protection even in colder months?

Though the risk of fleas and ticks is reduced during the winter, it is never zero. Fleas can survive in winter by hiding in sheltered or warmer areas. Moreover, most tick species are also prevalent throughout the year. Therefore, skipping treatments during winter may lead to infestations or diseases.

Can I use Frontline Plus on a pregnant dog?

When used according to the label, Frontline Plus is typically considered acceptable for use in breeding, pregnant, and lactating dogs when administered as indicated. However, you should talk to a vet before using any treatment on a pregnant dog.

Can I use Frontline Plus on any breed of dog?

Generally, Frontline Plus is considered acceptable for use in most dog breeds. However, some dogs may have different sensitivities. Therefore, you should consider your dog's sensitivities when using any treatment. If you are concerned about your dog's sensitivity, consult a vet before using it.

Can my dog get wet right after applying Frontline Plus?

Your dog should be dry at the time of application and should remain dry for 24 hours after application.

Can I use Frontline Plus for Dogs with other treatments?

You should use Frontline Plus for dogs with other treatments with caution, only under the guidance of a veterinarian. Consult a vet before combining it with other veterinary treatments, such as steroids, antibiotics, anesthetics, antihistamines, NSAIDs, or other topical treatments.

Frontline Plus Reviews

4.7
Average Rating 4.7 Based on 256 Reviews
  • 5 star
     186
  • 4 star
     67
  • 3 star
     1
  • 2 star
     0
  • 1 star
     2
72%
Recommend
72% of Reviewers Recommend This Product
Write A Review
4.7/5
Average Rating 4.7
Based on 256 Reviews
Trusted Topical Care Aug 16, 2026
Simple application for regular flea and tick care.
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Trusted Topical Care Aug 09, 2026
Simple application and convenient flea protection.
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Reliable Classic Aug 02, 2026
A dependable option that continues to deliver solid results.
Was this review helpful? 0 1
A Trusted Classic Jul 26, 2026
A trusted classic. I’ve used it for years and it still works reliably.
Was this review helpful? 0 1
Consistent Defense Jul 19, 2026
Reliable and easy monthly use.
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Proven Choice Jul 12, 2026
Consistent flea control every time.
Was this review helpful? 0 1
Trusted Solution Jul 05, 2026
Always dependable for flea control.
Was this review helpful? 0 1
Reliable Spot-On Jun 21, 2026
Keeps fleas under control consistently.
Was this review helpful? 1 0
Trusted Solution Jun 14, 2026
Keeps flea infestations under control.
Was this review helpful? 0 0
Trusted Care Jun 07, 2026
Keeps flea issues under control.
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