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Heartgard Plus for Dogs

4.8/5 (361 Reviews)
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  • Information
  • Directions
  • Safety
  • Benefits
  • Heartgard Plus FAQ
Information
Heartgard Plus
  • Pet
    Dog
  • Treatment For
    Heartworms
  • Health Benefits
    Internal Parasite Protection
  • Product Type
    Chewable Tablet
  • Parasites Covered
    Heartworms, Intestinal worms
  • Protects For
    One month
  • Recommended For
    6 weeks and older puppies
  • Key Ingredients
    Ivermectin, Pyrantel Pamoate

What is Heartgard Plus for Dogs?

Heartgard Plus for dogs is a vet-recommended heartworm disease preventive, providing proven protection for more than 30 years. It comes as a delicious, real-beef chew that most dogs love, making it the #1 dog-preferred chew, according to the manufacturer. Heartgard Plus chews don't just protect from heartworm disease; the treatment also ensures your dog is safe from two species of roundworms and three species of hookworms.

This monthly heartworm preventive for dogs is suitable for puppies from six weeks of age, allowing prevention of the deadly heartworm disease from a young age. It is available in three different dosage strengths to suit dogs of all sizes.

Suitable For

Heartgard Plus is suitable for puppies and dogs from 6 weeks of age.

Heartgard Plus Indications

  • Prevents heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis).
  • Treats & controls roundworms (Toxocara canis, Toxascaris leonina).
  • Treats & controls hookworms (Ancylostoma caninum, Ancylostoma braziliense, Uncinaria stenocephala).

Ingredients: Ivermectin, Pyrantel.

Directions
How to Use Heartgard Plus for Dogs

  • Heartgard Plus should be given orally once every month. Administer it on or about the same day of each month.
  • It can be offered to the dog by hand. To prevent intestinal obstruction or choking, encourage the dog to chew the treatment rather than swallowing it whole.
  • You may break the chew into pieces for dogs that swallow treats whole. You may also add the chew to a small amount of your dog's favorite food, ensuring the dog finishes the food and completes the dose. If the dog misses a part of the dose, redose.
  • Administer it monthly when mosquitoes are active. Give the first dose after your dog's first seasonal exposure to mosquitoes and administer the final dose within one month of the dog's last exposure.
  • When replacing another heartworm preventive with Heartgard Plus, give the first dose of Heartgard Plus within one month of the last dose of the former preventive.
  • In case you miss or forget a dose, give one chew immediately and resume with the monthly dosing schedule.

The table below shows available packs of Heartgard Plus with their dosage strengths.

Dog Size Dog Weight (lbs) Pack Color Ivermectin Strength (mcg) Pyrantel Strength (mg) Doses Administered
Small Dogs Up to 25.0 Blue 68 57 One
Medium Dogs 26 – 50.0 Green 136 114 One
Large Dogs 51 – 100.0 Brown 272 227 One
For dogs over 100.0 lbs, administer the appropriate combination of Heartgard Plus Chews.
Safety

For Dogs:

Heartgard Plus is not effective against adult heartworms (Dirofilaria immitis). Dogs should be tested for existing heartworms before starting heartworm preventive treatment. Infected dogs should be treated to remove heartworms at the discretion of a veterinarian. Do not use Heartgard Plus in puppies under 6 weeks of age.

Clinical trials referred to in the label suggest that Heartgard Plus can be used with anthelmintics, antibiotics, vaccines, flea collars, shampoos, dips, and steroid preparations. These chews are safe at the recommended dose level in pregnant, breeding and stud dogs.

For Humans:

Keep Heartgard Plus out of reach of children, uninformed people and pets. Wash hands after handling the product.

Are there Any Specific Storage Instructions for Heartgard Plus?

You should store Heartgard Plus between 68°F - 77°F (20°- 25°C) with excursions permitted between 59°F - 86°F (15°- 30°C). Protect these chews from light.

Benefits
  • #1 dog-preferred chew: Comes as a delicious, real beef chew that dogs readily accept.
  • Vet-recommended: Providing proven protection to dogs for more than 30 years.
  • Broad-spectrum worm coverage: Prevents heartworm disease and treats & controls two species of roundworms and three species of hookworms.
  • Safe & reliable: Suitable for use in puppies as young as six weeks, as well as pregnant and breeding dogs.
Heartgard Plus FAQ

Is Heartgard Plus safe?

Heartgard Plus chews are well-tolerated, have been trusted over 2 billion times and are the #1 vet-recommended heartworm preventive, according to the manufacturer.

How frequently should I administer Heartgard Plus chews?

You should administer Heartgard Plus once a month, throughout the year.

How does Heartgard Plus work?

Heartgard Plus contains ivermectin and pyrantel. Ivermectin targets the tissue stage of heartworm larvae (Dirofilaria immitis) and kills them. It allows the immune system of dogs to identify and inactivate these larvae before they grow into adult heartworms. On the other hand, pyrantel treats and controls intestinal worms, including roundworms and hookworms.

Can I bathe my dog after giving Heartgard Plus?

Heartgard Plus is an oral treatment. Bathing or shampooing your dog should not impact the efficacy of this preventive.

What is a safe age to start giving my dog Heartgard Plus?

Heartgard Plus is safe to use on puppies from 6 weeks of age with no minimum weight requirement. Ensure that your dog is tested for any existing heartworm infection before starting the treatment.

Do I need to administer Heartgard Plus to all of my dogs?

All 50 states of the United States have reported the heartworm disease. A single bite from an infected mosquito can transmit heartworm disease to your dog, so the risk is real. Therefore, it is necessary to administer heartworm preventive to all dogs in the household, all year round, to prevent the infection.

What happens if I miss a dose of Heartgard Plus?

If you miss a dose, give a chew immediately and resume with the monthly dosing schedule from the following month.

Will my dog take Heartgard Plus?

Heartgard Plus comes in a delicious real beef chew that dogs love and take without fuss.

Is it necessary to give Heartgard Plus during winter?

The risk of heartworms may be lower during winter, but it does not vanish. Therefore, you should give your dog Heartgard Plus throughout the year for continuous protection against potentially deadly heartworm disease.

Heartgard Plus Reviews

4.8
Average Rating 4.8 Based on 361 Reviews
  • 5 star
     311
  • 4 star
     46
  • 3 star
     2
  • 2 star
     0
  • 1 star
     2
86%
Recommend
86% of Reviewers Recommend This Product
Write A Review
4.8/5
Average Rating 4.8
Based on 361 Reviews
Heart Protection Mar 31, 2026
Keeps heartworm prevention simple and reliable.
Was this review helpful? 0 1
Monthly Must Mar 24, 2026
Keeps my dog’s heartworm protection consistent.
Was this review helpful? 1 1
Heart Safety Mar 17, 2026
Keeps heartworm protection on track every month.
Was this review helpful? 1 1
Trusted Care Mar 10, 2026
Keeps my dog safe from heartworms every month.
Was this review helpful? 1 1
Heartworm Hero Mar 03, 2026
Reliable heartworm prevention with a tasty chew.
Was this review helpful? 0 0
Must-Have Feb 22, 2026
Easy heartworm protection I trust every month.
Was this review helpful? 0 0
Nuheart Generic Feb 19, 2026
Got what I ordered, didn't wait long and the prices were outstanding!
Was this review helpful? 0 0
Trusted Guard Feb 15, 2026
Reliable heartworm protection I never skip.
Was this review helpful? 0 0
Impressive Feb 08, 2026
I had used it for the first time and I am really impressed.
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Awesome Feb 01, 2026
It is indeed an awesome heartworm preventive.
Was this review helpful? 0 0
One of the Best Jan 25, 2026
I am happy to have found the best heartworm preventive.
Was this review helpful? 0 0
The Best Jan 18, 2026
Surely the best heartworm preventive.
Was this review helpful? 0 0
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