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Nexgard Plus for Dogs

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4.0/5 (1 Reviews)
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  • Information
  • Directions
  • Safety
  • Benefits
Nexgard Plus
  • Pet
  • Treatment For
    Flea, Tick, Roundworm, and Hookworm
  • Health Benefits
    Internal and External Parasite Protection
  • Product Type
  • Parasites Covered
    Fleas, Ticks, Heartworms, Intestinal worms
  • Protects for
    1 Month
  • Recommended for
    Puppies and Dogs From 8 Weeks of Age
  • Key Ingredients
    Afoxolaner, Moxidectin, Pyrantel

Nexgard Plus Flea, Tick, Heartworm & Worm Treatment for Dogs

Nexgard Plus is a broad-spectrum treatment for dogs that provides protection against both external and internal parasites. This monthly treatment is indicated for use in eight weeks and older puppies and dogs, weighing four pounds or more. It is prepared in a delicious, beef-flavor, soft chewable form for easy administration and it is readily accepted by all dogs.

Nexgard Plus All-in-one Protection

Nexgard Plus is comprised of a powerful combination of three high-quality ingredients, i.e. afoxolaner, moxidectin, and pyrantel to offer protection against all the major parasites in one dose.

A single dose of Nexgard Plus every month,

  • Kills adult fleas before even they lay eggs
  • Protects against 4 types of ticks
  • Prevents heartworm disease
  • Treats and controls 2 roundworm species
  • Treats and controls 3 hookworm species

Flea Protection

  • Kills adult fleas before they lay eggs
  • Treats and prevents flea infestations
  • Starts killing fleas 4 hours after administration
  • Eliminates more than 99% of fleas 8 hours after infestation

Tick Protection

  • Protects against four common tick-types
  • Treats and controls black-legged tick, American dog tick, brown dog tick and lone star tick infestations
  • Achieves more than 90% effectiveness against ticks 48 hours post infestation

Worm Protection

  • Prevents heartworm disease caused by Dirofilaria immitis
  • Treats and controls three hookworm species, i.e. Ancylostoma canium, Ancylostoma braziliense and Uncinaria stenocephala
  • Treats and controls two roundworm species, i.e. Toxocara canis, Toxascaris leonina

How does Nexgard Plus work?

Nexgard Plus is made of afoxolaner, moxidectin and pyrantel (as pamoate salt). Afoxolaner inhibits neurotransmitter gamma-aminobutyric acid chloride channels, blocking the transfer of chloride ions across cell membranes. This results in uncontrolled activity of the nervous system and death of fleas and ticks.

Moxidectin interferes with neurotransmission in susceptible parasites causing paralysis and death of parasites, preventing heartworm disease caused by dirofilaria immitis. Pyrantel causes depolarization at the neuromuscular junction which results in paralysis and death of parasites such as roundworms and hookworms.


Afoxolaner, Moxidectin, Pyrantel (as pamoate salt)

How to Use Nexgard Plus for Dogs

  • Nexgard Plus is not effective against adult (D. immitis) heartworms. Therefore, dogs should be tested for any existing heartworm infestation prior to administration.
  • Weigh your dog and select the suitable pack according to their weight.
  • Give Nexgard Plus orally, once every month. It can be given with or without food ensuring the dog consumes the complete dose.
  • The minimum recommended dosage is 1.14 mg/lb (2.5mg/kg) afoxolaner, 5.45 mcg/lb (12mcg/kg) moxidectin and 2.27 mg/lb (5.0mg/kg) pyrantel (as pamoate salt).
  • Follow the table below for accurate dosage administration:
Dog Weight Afoxolaner Per Chew Moxidectin Per Chew Pyrantel Pamoate Per Chew Chewable Per Month
4 – 8 lbs 9.375 mg 45 mcg 18.75 mg One
8.1 – 17 lbs 18.75 mg 90 mcg 37.5 mg One
17.1 – 33 lbs 37.5 mg 180 mcg 75 mg One
33.1 – 66 lbs 75 mg 360 mcg 150 mg One
66.1 – 132 lbs 150 mg 720 mcg 300 mg One
For over 132 lbs dogs, administer the appropriate combination of Nexgard Plus chews
  • For use in dogs only
  • Avoid using in puppies younger than 8 weeks of age
  • Safe for puppies, heartworm-positive dogs and avermectin-sensitive Collies
  • Test your dog for heartworm disease before administration
  • Keep out of reach of children and pets
  • Store in original package at or below 25°C (77°F)


  • Safety is not evaluated in pregnant, breeding or lactating dogs
  • Use with caution in dogs with a history of seizures or neurologic disorders
  • Broad-spectrum treatment protects against multiple parasites
  • Delicious, soft, beef-flavored formula offers easy administration
  • Kills adult fleas before they lay eggs
  • Protects against four tick species
  • Prevents heartworm disease
  • Treats and controls two species of roundworms
  • Treats and controls three species of hookworms
  • Starts working within four hours after administrations
  • Can given to dogs as young as 8 weeks of age

Nexgard Plus Reviews

Average Rating 4.0 Based on 1 Reviews
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Excited to use it Aug 30, 2023
This is my first time using the Plus formula of Nexgard, but I'm assuming it'll do well just the way Spectra has done it for him.
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