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Advantage Multi (Advocate) For Dogs Large Dogs 20.1-55 lbs (Red)

4.8/5 (82 Reviews)
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Advantage Multi (Advocate) For Dogs Large Dogs 20.1-55 lbs (Red) 3 Doses
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Advantage Multi (Advocate)
  • Pet
  • Treatment For
    Flea, Worm, Heartworm
  • Health Benefits
    External Parasite Protection, Internal Parasite Protection
  • Product Type
    Topical, Spot-on
  • Parasites Covered
    Flea, Heartworm, Hookworm, Roundworm, Whipworm, Sarcoptic Mange, Ear Mite
  • Protects For
    1 Month
  • Recommended For
    Puppies 7 weeks of age and older
  • Key Ingredients
    Imidacloprid, Moxidectin

Advantage Multi (Advocate) Red For Large Dogs 20.1-55 lbs

Advantage Multi Red for Large Dogs is a broad-spectrum treatment for 7 weeks and older puppies and dogs that weigh between 20.1-55lbs. Advantage Multi For 20.1-55 lbs dogs is famously known as 5-in-1 treatment offering protection against a variety of internal and external parasites including heartworms, fleas, intestinal worms, and sarcoptic mange.

Advantage Multi Dogs (20.1-55lbs) Flea & Worm Treatment

  • Easy-to-use, topical formula
  • Multi-spectrum treatment that offers broader coverage
  • Kills adult fleas & treats flea infestations
  • Treats circulating D. immitis microfilariae in heartworm positive dogs
  • Prevents heartworm disease
  • Treats and controls intestinal worms including roundworms, hookworms, whipworms
  • Treats and controls sarcoptic mange
  • Can be given to your dog as a treat or with food
  • Lasts for the entire month
  • Safe to use on puppies from 7 weeks of age, weighing between 20.1-55lbs

Advantage Multi 20.1-55lbs Dogs Ingredients

Advantage Multi flea and worm treatment for 20.1-55lbs dogs is composed of two active ingredients; imidacloprid and moxidectin. After application, imidacloprid rapidly gets spread on dog's skin. It kills fleas as soon as they come in contact with the animal's skin. Moxidectin gets absorbed through the dog's skin into subcutaneous fat and the bloodstream. It prevents heartworm disease and treats intestinal worms and sarcoptic mange.

Manufacturer: Bayer

How to Use Advantage Multi (Advocate)

  • Get your canine tested for heartworm infestation before starting with this spot-on.
  • Treat him with Advantage Multi only if he is not infected with heartworms.
  • Check the pet’s weight and select a pack with weight range in which your canine’s weight falls.
  • Make the dog stand in a comfortable position.
  • Part fur between the shoulder blades until his skin is visible.
  • Break off the pipette’s seal.
  • Place the tip of on open pipette on the bare area.
  • Pour the entire content on the application site.
  • Allow the treated area to dry.
  • For large dogs, pour the content at 3-4 spots starting from the base of the skull to the base of the tail.
  • Advantage Multi for dogs should be applied topically once every month
  • The recommended minimum dose is 4.5mg/lb (10mg/kg) for imidacloprid and 1.1mg/lb (2.5mg/kg) for moxidectin.

Advantage Multi Dosage:

Dog Weight(Lbs)

Dog Weight(Kg)

Tube Size(mL)

Imidacloprid (mg)

Moxidectin (mg)

3 - 9

1.4 – 4.1




9.1 – 20

4.1 – 9.1




20.1 – 55

9.1 – 25.0




55.1 – 88

25.0 – 40.0




For over 88lbs dogs, use appropriate combination of Advantage Multi doses.

  • Dogs aging less than 7 weeks are not to be treated with Advantage Multi.
  • Do not treat canines allergic to the contents of this spot-on.
  • Treat your pet in an isolated space.
  • Keep the pack away from children and pets.
  • Do not smoke, drink or chew gum while treating your pet.
  • Clean your hands before and after application.
  • Don’t let your pet lick the application site.
  • Bathe your pet only after 48 hours of treatment.
  • Follow the dosage instructions mentioned in the manual.


  • Do not treat pregnant, sick, weak, lactating and breeding pets without consulting your vet.

Warning:Dogs of some breeds like collies including border collies are sensitive to moxidectin. They can suffer more or less serious adverse effects if treated at dose rates slightly higher than the recommended ones. Consequently, dosing must be as accurate as possible.

What is Advantage Multi(Advocate)?

Advantage Multi, also known as Advocate is one of the most sought after treatments from the house of Bayer. Advantage Multi kills and controls fleas, heartworms, gastrointestinal worms (hookworm, roundworm and whipworm), sarcoptic mange, demodicosis, and ear mite infestation in canines. This topical solution is easy to apply and tested safe for adult canines and puppies older than 7 weeks of age. This powerful parasitic preventive works against internal and external pests for an entire month. Using Advantage multi ensures safety from the unhealthy infestations irrespective of the dog’s breed.

Advantage Multi: Key Takeaways

  • Easy and hassle free application
  • Kills 100% fleas within 12 hours of application
  • Prevents heartworm infestation in dogs
  • Destroys and controls the growth of gastrointestinal worms excluding tapeworms
  • Works efficiently against lice, ear mites, demodex mites and sarcoptic mange
  • Quick mode of action
  • Remains effective for 30 days
  • Cost effective, all in one spot-on
  • Freedom from remembering different dates for flea treatment, worming and heartworm dose

What is the ideal age for my puppy to use Advantage Multi?

Advantage Multi for dogs is recommended for use in puppies from as young as 7 weeks of age, weighing 3lbs or more.

How does Advantage Multi work?

Advantage Multi For Dogs is made of two active ingredients; imidacloprid and moxidectin. Once applied, imidacloprid quickly gets spread across dog's skin and coat. It kills fleas as soon as they come in contact with the animal's skin. Moxidectin gets absorbed through dog's skin into subcutaneous fat and the bloodstream. It prevents heartworms, treats and controls gastrointestinal worms, and treats sarcoptic mange infections.

How often should I use Advantage Multi on my dog?

Advantage Multi should be used all year-round, once every month for protection against fleas, heartworms, and intestinal worms throughout the year.

Which Advantage Multi dose should I use if my dog weighs more than 88lbs?

If your dog weighs more than 88lbs, use an appropriate combination of Advantage Multi doses. Consult a vet if required.

Can I bathe my dog after applying Advantage Multi?

It is recommended bathing the dog prior to the treatment. Apply the dose once dog's skin is completely dry. Avoid shampooing as often as once a week as it can diminish product efficiency against fleas. Use a soap-free pet shampoo instead.
Avoid shampooing your pet as often as once a week as it can diminish product efficiency against fleas. Use a soap-free pet shampoo instead. Shampooing 90 minutes after application does not lower the effectiveness against heartworms. Water immersion or shampooing four days after product usage does not hamper its efficiency against fleas.

What happens if I miss a dose of Advantage Multi?

Advantage Multi For Dogs is a monthly treatment. If you miss a dose, apply one immediately as soon as you recollect dosing and continue with monthly dosing schedule.

What are the packaging specifications of Advantage Multi for dogs?

Advantage Multi for dogs is available in 3 doses, 6 doses, and 12 doses pack size.

Advantage Multi (Advocate) Reviews

Average Rating 4.8 Based on 82 Reviews
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Highly effective oin worms Nov 04, 2019
My pup got a major relief from worms. All thanks to Advantage Multi
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Effective and long lasting Oct 22, 2019
Unlike other products that do not last long Advantage Multi gives month long protection from parasites.
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works fast Oct 09, 2019
Does not take ages to kill fleas.
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Provides Bonanza Protection Sep 22, 2019
Advantage multi is a bonanza product for my Fido as it not only treats fleas and ticks but also combats gastrointestinal worms from him.
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Multi spectrum treatment Sep 13, 2019
My pooch was suffering from fleas and ticks that made me fear of her having heartworms, so I switched to using this multi spectrum treatment which works great
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Cost effective treatment Aug 29, 2019
Have used many products for my dog but this treatment is way better and cost effective than others
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Easy To Use Jul 24, 2019
We just adopted a dog and used this. Advantage Multi is great and so easy to use. We recommend it to other pet parents.
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Flea Free Fido Jul 15, 2019
I am so happy to see my dog relaxed and flea free after using this product
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Keeps my dog safe Jun 26, 2019
Great product and easy to apply and well worth the money spent to keep my dog healthy
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Good Product Jun 10, 2019
Single treatment for fleas and heart worms. Works great.
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