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Frontline Plus for Cats

4.7/5 (262 Reviews)
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  • Information
  • Directions
  • Safety
  • Benefits
  • Frontline Plus FAQ
Information
Frontline Plus
  • Pet
    Cat
  • Treatment For
    Flea & Tick
  • Health Benefits
    External Parasite Protection
  • Product Type
    Topical, Spot-on
  • Parasites Covered
    Flea, Flea eggs & larvae, Tick, Chewing Lice
  • Protects For
    1 Month
  • Recommended For
    Kittens 8 weeks of age and older
  • Key Ingredients
    Fipronil and (S)-Methoprene

What is Frontline Plus for Cats?

Frontline Plus for cats is a fast-acting and long-lasting treatment for protection from fleas and ticks. It effectively eliminates all life stages of fleas (eggs, larvae, and pupae) and ticks (larvae, nymphs, and adults). This monthly topical treatment prevents fleas and ticks from maturing and reproducing, which helps reduce the risk of new infestations.

When used as indicated, this spot-on treatment for cats is considered safe for most cat breeds, including breeding, pregnant and nursing cats. Frontline Plus for ticks reduces the risk of tick-borne diseases, such as Lyme disease, by killing the vector ticks. This flea and tick treatment for cats has been trusted by cat parents for over 20 years.

Suitable For

Frontline Plus for cats is suitable for kittens and cats from 8 weeks of age, weighing over 1.5 lbs.

Frontline Plus for Cats Indications

  • Kills fleas.
  • Prevents all flea life stages from developing by killing flea eggs, larvae and pupae.
  • Stops existing flea infestations and prevents new infestations from establishing.
  • Reduces the risk of flea allergy dermatitis by killing fleas.
  • Eliminates chewing lice infestations.
  • Kills all life stages of ticks (larva, nymph and adult), including brown dog ticks, black-legged (deer) ticks, American dog ticks and lone star ticks.
  • Helps reduce the risk of Ehrlichiosis, Lyme disease and other tick-borne diseases by killing vector ticks.

Ingredients: Fipronil, S-methoprene

Directions
How to Use Frontline Plus for Cats

  • Remove a pipette (applicator) from the package.
  • Open the applicator.
  • Snap the tip of the applicator by holding it upright with the foil side toward you.
  • Part your cat's hair between the shoulder blades.
  • Place the tip of the applicator just above your cat's skin and squeeze.
  • Apply the entire contents of the applicator in a single spot, ensuring you apply the liquid directly onto the skin.
  • Do not apply the liquid on top of the cat's hair coat.
  • Avoid contact with the treated cat until dry.

The table below displays the available packs of Frontline Plus for cats.

Frontline Plus for Cats Dosing Table:

Cat Size Cat Weight Volume Active Ingredients (g/L) Doses Administered
All Above 1.5 lbs 0.50 ml 9.8% Fipronil
11.8% (S)-methoprene
One
Safety

For Cats:

Frontline Plus for Cats is for external use on kittens and cats only. Do not administer it orally. It is not indicated for kittens younger than 8 weeks of age or weighing less than 1.5 lbs. This topical treatment can be used in breeding, pregnant, and lactating cats when applied as indicated. For your cat's safety, avoid the product's contact with their eyes or mouth and do not allow the cat to ingest the treatment.

For Humans:

Frontline Plus is not indicated for use in humans. Keep this topical product out of the reach of children and uninformed people. Do not allow children or anyone to come in contact with the application site until it is dry.

General:

You should not store or use the product near heat or open flame. Do not contaminate water, food or feed during storage and disposal. Wash your hands thoroughly after handling the product.

Are there Any Specific Storage Instructions for Frontline Plus?

Store it in the original container.

Benefits
  • Comprehensive coverage: Protects from fleas, four tick species and chewing lice.
  • Breaks the cycle: Prevents life stages of fleas and ticks from developing, preventing future infestations too.
  • Fast-acting & long-lasting: Starts working quickly after administration and stays effective throughout the month.
  • Waterproof: Stays effective even after bathing or water immersion, when left to dry for 24 hours after application.
  • Safe and reliable: Indicated for kittens from 8 weeks, including breeding, pregnant, or lactating cats.
Frontline Plus FAQ

How does Frontline Plus for Cats Work?

Frontline Plus for Cats contains fipronil and S-methoprene. These active ingredients spread across the cat’s skin and coat from a single point after application. The formula localizes in the cat's hair, on the surface of the skin and in the sebaceous glands. These glands replenish the formula continuously and protect cats, even when they get wet. Fipronil kills adult parasites while S-methoprene breaks the life cycle and prevents future infestations.

Is Frontline Plus safe for cats?

When used as directed, Frontline Plus is suitable for kittens from 8 weeks of age and above 1.5 lbs of body weight. It can be used on pregnant, breeding and lactating cats.

Can I use Frontline Plus for Cats on other animals?

Frontline Plus for Cats is approved for use on kittens and cats only. You should not use this treatment on any other animal.

Is it safe to use Frontline Plus for Cats with my cat's other treatments?

You should use Frontline Plus for Cats with your cat's other treatment only under the guidance of a vet. Consult your veterinarian when combining it with antibiotics, steroids, anesthetics, antihistamines, NSAIDs, or other oral treatments.

Can I bathe my cat right after applying Frontline Plus?

Your cat should be dry at the time of application and should remain dry for 24 hours after applying the treatment.

Is there a minimum weight or age criterion for Frontline Plus for cats?

Frontline Plus for Cats is indicated for use in kittens and cats that are at least 8 weeks old and weigh over 1.5 lbs.

How frequently should I administer Frontline Plus on my cat?

You should apply a dose of Frontline Plus for Cats once every month and treat your cat year-round for your cat's uninterrupted protection.

Can I use Frontline Plus on any breed of cat?

Generally, Frontline Plus is considered acceptable by most cat breeds. However, some cats may have different sensitivities. Therefore, you should consider your cat's sensitivities when using any treatment. If you are concerned about your cat's sensitivity, consult a vet before using it.

Frontline Plus Reviews

4.7
Average Rating 4.7 Based on 262 Reviews
  • 5 star
     193
  • 4 star
     68
  • 3 star
     1
  • 2 star
     0
  • 1 star
     0
73%
Recommend
73% of Reviewers Recommend This Product
Write A Review
4.7/5
Average Rating 4.7
Based on 262 Reviews
Easy Flea Routine Aug 18, 2026
Quick to apply and simple to include in regular care.
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Easy Flea Routine Aug 11, 2026
Quick application and easy to include in regular care.
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Consistent Results Aug 04, 2026
Always provides steady protection against fleas and ticks.
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Consistent and Dependable Jul 28, 2026
Still one of the most dependable flea treatments out there.
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Trusted Formula Jul 21, 2026
Always dependable for flea control.
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Reliable Use Jul 14, 2026
Keeps fleas away consistently.
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Consistent Results Jul 07, 2026
Keeps fleas under control every time.
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Consistent Care Jun 30, 2026
Keeps fleas away month after month.
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Consistent Results Jun 23, 2026
Works every time for flea control.
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Reliable Care Jun 16, 2026
Consistent protection against fleas.
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Reliable Option Jun 09, 2026
Works consistently against fleas.
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Reliable Care Jun 02, 2026
Dependable flea protection every time.
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