Frontline Plus (COMBO) for Large Dogs 45-88 lbs (Purple)

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Frontline Plus (COMBO) for Large Dogs 45-88 lbs (Purple) 3 Pipette
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Frontline Plus (COMBO)
  • Pet
  • Treatment For
    Flea & Tick
  • Health Benefits
    External Parasite Protection
  • Product Type
  • Parasites Covered
    Adult fleas, Ticks, Flea eggs, larvae, Pupae, Chewing lice
  • Protects For
    One month
  • Recommended For
    8 weeks and older puppies
  • Key Ingredients
    Fipronil, s-Methoprene

Frontline Combo - (Frontline Plus) for Dogs

Frontline Combo also known as Frontline Plus is a widely used and vet recommended flea and tick control product for dogs. The spot-on treats and prevents fleas, ticks, and biting lice within few hours of application. The monthly treatment prevents the multiplication of fleas by inhibiting the development of eggs and larvae and pupae originating from eggs laid by adult fleas for eight weeks after application. The fast-acting formulation prevents flea allergy dermatitis and sarcoptic mange infestation in dogs. The long-lasting effect stays for 4 weeks and waterproof property makes it work even when your dog goes wet. Frontline Combo can be used during pregnancy and lactation.

Frontline Combo is recommended for use on puppies over the age of 8 weeks.

How it works?

Fipronil is an insecticide that blocks pre-and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects. Fipronil kills fleas within 24 hours and ticks and lice within 48 hours post-exposure. (S)-methoprene is an insect growth regulator that impairs the development and death of the growing stages of fleas. It is effective in preventing flea larvae and pupae from developing, which prevents contamination of the environment of treated animals with the immature stages of fleas. Both (S)-methoprene and fipronil, together with its major metabolite, are well distributed in the hair coat of a dog within one day after application and stays effective for one full month.

Important Note: Merial is now acquired by Boehringer Ingelheim. So, the manufacturer’s name on product packs may vary according to the available stock.

Ingredients: Fipronil, (s)-methoprene

  • Weigh your pet first and choose pack as per the weight.
  • Open one foil pouch and remove applicator.
  • Hold applicator in upright position away from your face and snap tip open by bending it and folding it back on itself.
  • The dog should be standing for easy application. Part the hair and place applicator tip against the skin between shoulder blades.
  • Squeeze applicator firmly applying entire contents directly to skin.
  • Do not have contact with treated area until it is completely dry.
  • For larger dogs: The entire contents of one applicator should be applied evenly at two, three or four spots, at different sites along the back of the dog between the shoulders and the base of the tail.
  • Repeat the treatment every month.
  • Store it in a cool and dry place.
  • Keep at a place inaccessible to children and pets.
  • Wash hands with soap and water after treatment.


  • Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
  • Do not use in cats, rabbits and ferrets.
  • Stops and prevents flea and tick infestation
  • Fast acting formulation kills fleas and ticks within few hours of administration
  • Prevents all life stages of flea – eggs, larvae and pupae from developing
  • Kills adult fleas, flea eggs and flea larvae
  • Treats chewing lice on both puppies and dogs
  • Controls flea allergy dermatitis, sarcoptic mange and other parasitic diseases
  • Destroys and prevents all tick species including brown dog ticks, paralysis ticks, deer ticks, American dog ticks and lone star ticks
  • Water resistant continues works even after exposure to water and sunlight

Frontline Plus (COMBO) Reviews

Average Rating 4.8 Based on 27 Reviews
81% of Reviewers Recommend This Product Write A Review
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I always use this product Jun 29, 2022
We have two big dogs and Frontline works perfectly on them.
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Best Formula Jan 03, 2022
After started using this amazing treatment for my doggo, I have never seen any annoying fleas back on my pal. Thumbs up!
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Great Product! Dec 03, 2021
No other product worked as effectively as this. Would strongly recommend this.
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Excellent Product Sep 20, 2021
The product exactly does what it is advertised for. loved it!
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Best Flea Control Jul 11, 2021
Best option to control re-infestation for a long time. It really controls those nasty hoppers from developing in more numbers.
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Vet-recommended Jun 13, 2021
I think my vet recommended us the best! Frontline worked really well for my pooch.
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Amazing Product May 06, 2021
I couldn't better than this. This product has worked amazingly for my fido
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Great Product! Apr 12, 2021
Best and effective way to protect our furry friends against flea and tick. Would recommend this.
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Best and effective treatment Mar 30, 2021
It is my best choice when it comes flea and tick treatment. Using since many years but never found this treatment at this much affordable rates. Amazing!
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Best and effective Mar 24, 2021
Best and effective product I have ever used for my canines. Thanks!
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